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Effect of (3-phenyl lactic acid on platelet aggregation, thrombosis, and plasma cAMP content

   
@article{APS8616,
	author = {Liang Zhu and Yi-De Shao and Jue-Ying Wang and Dan-Li Lin and Chun-Lu Gu and Yong-He Li and Jian-Guo Gu and Hua-Juan Dai and Ji-Chang Dong and Fen Xue},
	title = {Effect of (3-phenyl lactic acid on platelet aggregation, thrombosis, and plasma cAMP content},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {(+)(3-Phenyl lactic acid (PAL) 0.25-0.5 and 0.85 mg/ml  PRP in vitro markedly inhibited rabbit platelet aggreation induced  by collagen (18.6  vg/ml PRP) and  by  ADP   (12.8 vmol/ml PRP), respectively. The latter was antagonised by CaCl2  (2.5 mmol/L).  PLA  100 mg/kg iv significantly inhibited thrombosis in rats, but 50 mg/kg iv had no  effect  on  thrombosis in rats and on the cAMP content of plasma in rabbits. These results suggest that the effect of PLA on platelet may not be related directly to cAMP.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8616}
}