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Effects of bleomycins on synchronized cells by centrifugal elutriation

   
@article{APS8597,
	author = {De-Zheng Wu and Peter Keng},
	title = {Effects of bleomycins on synchronized cells by centrifugal elutriation},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Chinese hamster ovary  (CHO) cells and human oat cell lung carcinoma (ME-MAR) cells were synchronized by centrifugal elutriation. The  study of bleomycins (BLM) cytotoxicity to CHO cells showed that G2M phase was sensitive to BLM, S phase intermediate, and G1 phase resistant. In synchronized MEMAR cells the late S phase was sensitive, G2M phase intermediate, and G1 phase resistant to BLM toxicity. DNA distribution patterns measured by flow cytometry showed that a significant G2 block was obtained in CHO cells exposed to BLM 4-15 vg/ml. BLM also prevented  cell  passage from S to G2 phase. A similar G2 block was found in MEMAR cells. However, no S phase accumulation was found up to BLM 15 vg/ml.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8597}
}