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Evaluation of anti-arrhythmic potency of naltrexone in isolated ischaemic rat heart

  
@article{APS8562,
	author = {Xiao-Lui Liu and Chi-Pui Mok and Ying-Siu Lee and Tak-Mingi Wong},
	title = {Evaluation  of  anti-arrhythmic potency of  naltrexone in isolated ischaemic rat  heart},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The anti-arrhythmic properties of naltrexone were evaluated by an anti-arrhythmic screening test using  the isolated  ischaemic perfused rat heart preparation. The maximal anti-arrhythmic effect of naltrexone was attained 60 min after its administration and the potency based on cardiac anti-arrhythmic protection (CAP)50 was 750 nmol/heart with 95% confidence limits of 674-836 nmol/heart. The time required to reach the maximal response and the anti-arrhythmic potency were much longer than and comparable to that of naloxone, respectively.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8562}
}