@article{APS8560,
author = {Zuo-Hua Du and Han Guan Liu and Fan Dian Zeng and Chong-Jia Hu},
title = {Effects of dauricine combined with other anti-arrhythmia agents on electrically induced ventricular fibrillation in rabbits},
journal = {Acta Pharmacologica Sinica},
volume = {9},
number = {1},
year = {2016},
keywords = {},
abstract = {The electrically induced vencricular fibriIJation threshold (VFT) in rabbits increased in linear relationship with the dose of dauricine (iv l.2-10 mg/kg). 4 kinds of anti-arrhythmia drugs. amiodarone (20 mg/kg), lidocaine (10 mg/kg), phenytoin sodium (25 mg/kg) and propranolol (1.5 mg/kg) increased VFT significantly but verapamil (0.5 I mg/kg) did not do so. The results of simultaneous administration of dauricine at high and low doses with other anti-arrhythmia drugs mentioned above separately showed that the effects of dauricine (5 mg/kg) with amiodarone (10 mg/kg), dauricine ( 2.7 mg/kg ) with lidocaine (5 mg/kg), as well as dauricine (1.2, 5 mg/kg) with propranolol (0.8 mg/kg) were simply additive. while the effect of dauricine (5 mg/kg) with lidocaine (5 mg/kg) potentiated the simply additive.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8560}
}