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Inhibitory regulations of ohmefentanyl and morphine on postsynaptic dopamine receptors

  
@article{APS8555,
	author = {Yi-He Yao and Zhi-Qiang Chi},
	title = {Inhibitory regulations of ohmefentanyl and morphine on postsynaptic dopamine receptors},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Ohmefentanyl, a highly selective agonist for u opioid  receptors,  produced  a naloxone-reversible inhibition of amphetamine-induced  ipsilateral and apomorphine-induced contralateral rotation in rats with 6-hydroxy-dopamine-induced  unilateral lesion of nigrostriatal neurons. Acute treatments of ohmefentanyl and morphine decreased dopamine receptor density and inhibited the enhanced binding of [3H]spiperone to rat striatal dopamine receptors induced by denervation. It is proposed that these two  drugs probably have an indirect inhibitory  effect  on postsynaptic dopamine receptors in rat striatum.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8555}
}