@article{APS8555,
author = {Yi-He Yao and Zhi-Qiang Chi},
title = {Inhibitory regulations of ohmefentanyl and morphine on postsynaptic dopamine receptors},
journal = {Acta Pharmacologica Sinica},
volume = {9},
number = {1},
year = {2016},
keywords = {},
abstract = {Ohmefentanyl, a highly selective agonist for u opioid receptors, produced a naloxone-reversible inhibition of amphetamine-induced ipsilateral and apomorphine-induced contralateral rotation in rats with 6-hydroxy-dopamine-induced unilateral lesion of nigrostriatal neurons. Acute treatments of ohmefentanyl and morphine decreased dopamine receptor density and inhibited the enhanced binding of [3H]spiperone to rat striatal dopamine receptors induced by denervation. It is proposed that these two drugs probably have an indirect inhibitory effect on postsynaptic dopamine receptors in rat striatum.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8555}
}