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Relationship between diethyl lipoamide (dela)-induced tissue hypoxia and radiation-protective effect in mice

   
@article{APS8551,
	author = {De-zheng Wu and Li-Ii Liu and Dong-ping Liu},
	title = {Relationship between  diethyl  lipoamide  (dela)-induced tissue hypoxia  and  radiation-protective effect in mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Subcutaneous tissue O2 tension and splenic blood flow were determined by O2 microelectrode and dye (neutral red)-distribution technique. DELA at radioprotective dose levels (55 and 110 mg/kg) decreased both subcutaneous tissue O2 tension and blood supply  to spleen resulting in tissue hypoxia. The DELA-induced tissue hypoxia  was dose-dependent and followed the same time course as the radioprotective effect.    These results suggest that the tissue hypoxic effect of DELA is responsible for its radioprotective action.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8551}
}