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Identifiability of nonlinear compartmental models for plasma protein binding of sulfa drugs

   
@article{APS8546,
	author = {Shao-xiong He and Wen-bai Zhang and Si-lan Zhao and Tuan-hua Huang and Bing-xian Huang},
	title = {Identifiability of  nonlinear compartmental models for plasma protein binding of sulfa drugs},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {After iv sulfamethoxypyridazine (SMP) or sulfadiazine  (SD) 200 and 300 mg/kg in rats,blood levels were assayed and the system parameters were  identified with  one compartment (two subcompartments) and two compartment models. On the basis of these parameters. the plasma protein binding rates of SMP and SD were calculated and compared with those obtained by the method of equilibrium diajysis in vitro. The calculated plasma protein binding rates within the effective blood concentration ranges were 80-90% for SMP and 50-60 26 for SD. These results were  in  agreement  with those obtained in. vitro and in vivo. With a suitable model, we believe that the calculated plasma protein binding rate reflects the truth in vivo. In this paper. the new calculated methods of nonlinear system identifiability were presented.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8546}
}