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Pharmacokinetics of fluorocarbon blood substitute

  
@article{APS8545,
	author = {Xun-cheng Ding and Bin-wu Chen and Ju-fang Shen and Wen-hua Gu and Wen-juan Cao},
	title = {Pharmacokinetics of fluorocarbon blood substitute},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The pharmacokinetics of fluorocarbon emulsions (FCE) was investigated in rats and monkeys. The blood levels of FCE after  iv 15 g/kg  in 4 monkeys  decreased in 2 phases, the distributive phase and the eliminative phase, with half-lives of  3.8 h and 44 h, respectively. The pharmacokinctic parameters calculated according to the  two-compartment open model were:  a = 0.1846lh, (3 = 0.0106/h, K10 = 0.0470,K12 = 0.0920, K21 = 0.0612, V1 =0.4032 l/kg,   V2 = 0.6102 1/kg,  Vd = 1.2162 11 kg,  A =136 mg/ml,  B=50 mg/ml,   clearance K10 V1 = 0. 0190 l/h.  However, the blood FCE levels data after iv FCE 9 g/kg in rats adequately fitted to one-cornparment open model, t1/2 = 10 h.       After iv FCE  9 g/kg in rats  the  highest FCE level was found in splcen, moderate in liver and lowest in kidneys, indicating an accumulation in the reticuloendothelial system. FCE disappeared completely from all organs in 2 mopths,  which was in agreement with the results of pharmacokinetic analysis.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8545}
}