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Comparative epileptogenic properties of cefazolin and benzylpenicillin after lntracaudate micro-lnjectlon in rats

   
@article{APS8536,
	author = {G B De Sarro and M Calo and G Bagetta and R Anfosso and E Marmo and G Nistico and V Guarino},
	title = {Comparative epileptogenic properties of cefazolin and benzylpenicillin  after  lntracaudate micro-lnjectlon in rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The epileptogenic properties of cefazolin given unilaterally into the caudate nucleus of rats were compared with those by equimolar doses of benzylpenicillin.  Cefazolin produced a dose-dependent increase in locomotor activity, circling, stereotyped behavior and myoclonic jerks associated witb bigh voltage spikes and other bioelectric paroxysmal discharges.  In comparison to benzylpenicijjin. cefazolin was more powerful on a molar basis and the epileptogenic disorders were longer-lasting.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8536}
}