@article{APS8532,
author = {Yi-fan Han and Xian-yu Chen},
title = {Effects of anisodine and other cholinergic drugs on learning and memory in spatial discrimination of mice},
journal = {Acta Pharmacologica Sinica},
volume = {4},
number = {4},
year = {2016},
keywords = {},
abstract = {It has been recognized for a long time that some cholinergic drugs appear to affect the processes of information acquision, consolidation, maintenance and retrieval. Anisodine is a new muscarinic anticholinergic agent isolated from ScopoZia tangutica Maxim. It is similar to scopolamine both in chemical structure and in pharmacological properties. In this paper effects of anisodine. arecoline and hemicholinium on learning and memory were studied using spatial discrimination of mice as a model. Anisodine (l-5 mg/kg, ip) and hemicholinium (0.4-2.5 Ug. iv) inhibiting the physiological function of central cholinergic system impaired markedly the processes of acquisition. consolidation and retrieving of recent memory, while the remote memory remained unaffected. The role of anisodine on learning and memory appears to be specific and selective. Facilitation of acquisition was produced by arecoline 0.25-0.5 mg/kg (ip). but inhibition was obtained by 5-10 mg/kg. Arecoline 0.5 mg/kg effectively antagonized the disruptive effect of anisodine 5 mg/kg on acquisition process. The time span for consolidation of memory was },
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8532}
}