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Anti-inflammatory effect of bacillus subtilis neutral protease

   
@article{APS8530,
	author = {Zhong-da Zhou and Ping Wang and Xiao-lin Zhou},
	title = {Anti-inflammatory effect of bacillus subtilis neutral protease},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {A neutral peptidase was isolated from Bacillus subtilis  (A.S.   1. 398).   Intraduodenal injection of  this  protease  40 mg/kg showed a significant anti-inflammatory effect on acute egg albumin-induced edema of hind paws in rats and a weak fibrinolytic activity (60 Vg/ml) in vitro. The [l25I]protease by  intraduodenal injection was absorbable from small intestine. Acute ip LD50  in mice  was 45 (95% fiducial limits 27 and 55) mg/kg. Hence this protease has a low toxicity. strong anti-inflammatory effect.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8530}
}