@article{APS8497,
author = {Ji-ying Wei and Mao-lin Su and Min-jun Duan and Yuan-hai Chen and Xiao-mei Liu},
title = {Effects of nicardipine on vertebral vascular resistance in anesthetized dogs and spontaneous activity in mice},
journal = {Acta Pharmacologica Sinica},
volume = {4},
number = {2},
year = {2016},
keywords = {},
abstract = {In 7 anesthetized dogs, vascular resistance was measured by a mercury manometer connected distally to a constant rate pump with perfusion pressure as the indication of vascular resistance. Blood taken from right carotid artery was pumped at a constant rate into left vertebral artery. Intravenous injection of nicardipine (NC) 1, 5, 10 and 20 ILg/kg produced a greater reduction of vascular resistance of vertebral artery than .that of femoral artery. While l ILg/kg exhibited a greater vasodilation in the vertebral artery than in the femoral artery, the mean arterial pressure was not markedly affected. When 175mg/kg was given po, the spontaneous activity of mice diminished (p},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8497}
}