@article{APS8490,
author = {Dao-xing Ren and Lan-sun Huang and Xian-yu Zheng and Jin-lin Sun and Rui-zhen Tang and Chang Chen and Jun-shi Chen and Shou-ping Yao},
title = {Synthesis, toxicity and antimalarial effects of bispyroquine},
journal = {Acta Pharmacologica Sinica},
volume = {4},
number = {1},
year = {2016},
keywords = {},
abstract = {A new antimalarial agent was synthesized by introducing another pyrrolidine into amopyroquine to form 7-chlo-ro-4- (3',5'-di-pyrrolidin-l-y 1-methyl-4’-hyd roxy-phenyl) aminoquinoline, possessing dual pyrolidin-l-yl-methylphenolic side chain, named \"bispyroquine\" (M6407). It showed a strong schizontocidal activity against Plasmodium berghei and a low toxicity to mice. The therapeutic indices of bispyroquine and chloroquine were 37 and 9 by ig, 17.5 and l.3 by im, respectively. Hence bispyroquine is superior to chloroquine.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8490}
}