@article{APS8400,
author = {Wen-li ZHAO and Ze-hui GONG and Jian-hui LIANG},
title = {A new buprenorphine analogy, thenorphine, inhibits morphine-induced behavioral sensitization in mice},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {11},
year = {2016},
keywords = {},
abstract = {AIM:
To investigate effects of thenorphine, a new compound of partial agonist of mu-opioid receptor, on the locomotor activity and the behavioral sensitization to morphine in mice.
METHODS:
Locomotor activity was observed after administration of thenorphine or co-administration of thenorphine and morphine in mice. Mice were induced behavioral sensitization to morphine by intraperitoneal injection of 20 mg/kg morphine once daily for 7 d. Thenorphine was co-administrated with morphine to observe the effects of thenorphine on the development, transfer and expression of morphine-induced behavioral sensitization.
RESULTS:
A single dose of thenorphine (0.0625, 0.25, and 1.0 mg/kg) could dose-dependently inhibit the locomotor activity in mice (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8400}
}