@article{APS8398,
author = {Xiao-chuan LI and Chen YU and Wei-kang SUN and Gang-yi LIU and Jing-ying JIA and Yi-ping WANG},
title = {Pharmacokinetics of magnesium lithospermate B after intravenous administration in beagle dogs},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {11},
year = {2016},
keywords = {},
abstract = {AIM:
To develop a specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the pharmacokinetic study of magnesium lithospermate B (MLB), and study the pharmacokinetics of MLB after i.v. administration in beagle dogs.
METHODS:
Each beagle dog was iv administered MLB 3, 6, and 12 mg/kg random. The serum drug concentration was determined by specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays. The pharmacokinetic parameters were calculated by Drug and Statistics version 1.0 program.
RESULTS:
The calibration curve for MLB was linear over a range of 16-4096 microg/L with coefficients of correlation >0.999. The intra- and inter-day precisions (CV) of analysis were },
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8398}
}