@article{APS8385,
author = {Da-chuan LIU and Chuan-bing ZANG and Hong-yu LIU and Kurt POSSINGER and Shao-guang FAN and Elena ELSTNER},
title = {A novel PPAR alpha/gamma dual agonist inhibits cell growth and induces apoptosis in human glioblastoma T98G cells},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM:
To examine the effect of a novel peroxisome proliferator-activated receptor (PPAR) alpha/gamma dual agonist TZD18 on cell proliferation and apoptosis in human glioblastoma T98G cells and its possible mechanism.
METHODS:
RT-PCR, MTT, TUNEL, Flow cytometry, and Western blot analysis were employed.
RESULTS:
TZD18 inhibited the growth of T98G cells in a concentration-dependent manner, which was associated with a G1 to S cell cycle arrest. Besides, significant apoptosis was induced after treatment with a non-toxic dose of TZD18. During the process, the expression of Bcl-2 protein was down-regulated, while that of Bax and p27kip proteins was up-regulated, and the activity of caspase-3 was elevated. However, this effect appeared to be PPARalpha and PPARgamma independent since their antagonists could not reverse this effect.
CONCLUSIONS:
TZD18, a novel PPARalpha/gamma dual agonist, inhibited cell growth and induce apoptosis in human glioblastoma T98G cells in vitro, indicating a therapeutic potential for TZD18 in the treatment of glioblastoma.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8385}
}