@article{APS8377,
author = {Gisele LOPES and Vilma A F G GAZOLA and Sgarize B GALENDE and Wilson ALVES-DO-PRADO and Rui CURI and Roberto B BAZOTTE},
title = {Comparative acute effects of l-carnitine and dl-carnitine on hepatic catabolism of l-alanine and l-glutamine in rats},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM:
To compare the acute effects of l-carnitine (LCT) and dl-carnitine (DLC) on hepatic catabolism of l-alanine and l-glutamine in rats.
METHODS:
Livers from 24 h fasted and fed rats were perfused in situ. The substrates l-alanine (5 mmol/L) and l-glutamine (5 mmol/L) were employed. The gluconeogenic and ureogenic activity was measured as the difference between the rates of glucose and urea released during and before the infusion of l-glutamine or l-alanine.
RESULTS:
LCT (60 micromol/L) but not DLC (60 micromol/L and 120 micromol/L) increased the production of glucose and urea from l-glutamine. However, neither LCT (60 micromol/L and 120 micromol/L) nor DLC (60 micromol/L and 240 micromol/L) showed any significant effect on hepatic glucose and urea production from l-alanine.
CONCLUSION:
The results showed a different acute effect of LCT and DLC on the activation of hepatic gluconeogenesis and ureagenesis promoted by l-glutamine, reinforcing the idea that DLC could not replace LCT.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8377}
}