@article{APS8359,
author = {Lin CHANG and Jing ZHAO and Gui-zhong LI and Bin GENG and Chun-shui PAN and Yong-fen QI and Chao-shu TANG},
title = {Ghrelin protects myocardium from isoproterenol-induced injury in rats},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {9},
year = {2016},
keywords = {},
abstract = {AIM:
To investigate the cardiac protective effects of ghrelin in rat with myocardial injury induced by isoproterenol (ISO).
METHODS:
Rats were subcutaneously injected ISO 40 mg/kg/d with or without ghrelin 1 or 10 nmol/kg/d for 2 d. Hemodynamic parameters including mean arterial blood pressure and left ventricular pressure were measured at 12 h after the last injection with ISO and/or ghrelin. Plasma lactate dehydrogenase (LDH) activity, plasma and myocardial contents of malondialdehyde (MDA), and conjugated diene were measured. Plasma ghrelin and endothelin-1 levels were assayed using radioimmunoassay methods. Endothelin-1 and ghrelin mRNA were determined using RT-PCR.
RESULTS:
About 45 % (5/11) of rats after treatment with ISO alone died during experimental periods. However, no rats died after administration with ghrelin 10 nmol/kg/d (0/11, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8359}
}