@article{APS8335,
author = {Cheng-haung WANG and Tsung-hsing LEE and Yi-jung TSAI and Jong-kang LIU and Yann-jang CHEN and Lin-cheng YANG and Cheng-yuan LU},
title = {Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {8},
year = {2016},
keywords = {},
abstract = {AIM:
To investigate the effect of cyclin-dependent kinase 5 (Cdk5) inhibitor roscovitine on the morphine antinociceptive tolerance development in rats.
METHODS:
Tail-flick test as pain threshold measurement and intrathecal injection techniques were used.
RESULTS:
Intrathecal roscovitine infusion alone produced an antinociceptive effect. Tolerance was induced by continuous intrathecal infusion of morphine 5 microg/h for 5 d. Co-administration of intrathecal roscovitine 1 microg/h for 5 d enhanced the morphine antinociceptive effect in tolerant rats. It also caused a shift in the morphine antinociceptive dose-response curve to the left when co-administered with morphine during tolerance induction, and caused a 67 % reduction in the increase in the ED50 of morphine (dose producing 50 % of the maximum response).
CONCLUSION:
Cdk5 modulation is involved in the antinociceptive tolerance of morphine. Intrathecal roscovitine administration could attenuate this tolerance development.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8335}
}