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Pharmacokinetics of intragastric ipriflavone solid dispersion in rats.

   
@article{APS8317,
	author = {Ya-ping Li and Jian-jun Zhou and Xiang-ying Zhang and Yuan-ying Pei},
	title = {Pharmacokinetics of intragastric ipriflavone solid dispersion in rats.},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {11},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To evaluate pharmacokinetic behavior of ipriflavone solid dispersion in rats.
METHODS:
The plasma concentrations of ipriflavone in rats were determined by HPLC with UV detector.
RESULTS:
Plasma concentration-time curves after ig ipriflavone solid dispersion 250 mg.kg-1 in rats were fitted with one-compartment model. Pharmacokinetic parameters were as follows: Ke = 0.21 h-1, T1/2Ke = 5.19 h, Ka = 1.71 h-1, T1/2Ka = 0.41 h, Tmax = 0.67 h, Cmax = 429 micrograms.L-1, AUC = 3916 micrograms.h.L-1; The relative bioavailability of ipriflavone solid dispersion was 323%.
CONCLUSION:
Ipriflavone in solid dispersion was absorbed more effectively than that in physical mixture in rats.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8317}
}