@article{APS8310,
author = {Zhong-hua Liu and Jin-lian Li and Na Li and Chun-lin Tian and Kai-gao Zhang},
title = {Effect of tetrandrine on morphine dependence in isolated guinea pig ileum.},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {11},
year = {2016},
keywords = {},
abstract = {AIM:
To evaluate the effects of tetrandrine (Tet) and nimodipine (Nim) on the morphine (Mor) withdrawal response in the isolated guinea pig ileum.
METHODS:
The withdrawal contracture was elicited by addition of naloxone (Nal) (1 mumol.L-1) to the isolated naive ileum incubated with Mor (3 mumol.L-1) at 37.5 degrees C for 4 h or to the ileum obtained from Mor-dependent guinea pig.
RESULTS:
When Nim (0.01, 0.05, and 0.1 mumol.L-1) or Tet (1, 10, and 50 mumol.L-1) was added 1 min before Nal in the naive ilea bathed in Krebs solution containing Mor, or when the ilea from Mor-dependent guinea pigs were incubated with Nim (0.01, 0.05, and 0.1 mumol.L-1) or Tet (1, 10, and 50 mumol.L-1) for 15 min, or when Nim (5 and 10 mg.kg-1, i.p.) or Tet (15 and 30 mg.kg-1, i.p.) was administered in vivo to Mor-dependent guinea pigs, the Nal-precipitated withdrawal contracture was significantly decreased in a dose-dependent manner.
CONCLUSION:
Tet and Nim, Ca2+ channel blockers, could inhibit the Nal-precipitated Mor withdrawal response in the isolated guinea pig ileum.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8310}
}