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Research Center of Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221002, China.

   
@article{APS8309,
	author = {Xiao-yu Hou and Guang-yi Zhang},
	title = {Research Center of Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221002, China.},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {11},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the effect of dopamine receptor antagonists on anoxia-induced inhibition of Ca(2+)-calmodulin dependent protein kinase II (CCDPK II) activity in rat hippocampus and striatum.
METHODS:
Using the rat hippocampal and striatal slices under 95% N2 + 5% CO2, the activity of CCDPK II was examined by 32P-incorporation.
RESULTS:
Under anoxia for 30 min, the CCDPK II activity decreased to 29.2% and 27.0% of the control in rat hippocampal and striatal slices, respectively. Preincubation with Sch-23390 (a specific D1-like dopamine receptor antagonist), or domperidone (a specific D2-like dopamine receptor antagonist), resulted in a concentration-dependent attenuation of the anoxia-induced inhibition of CCDPK II activity which was preserved up to about 60%.
CONCLUSION:
Dopamine receptor stimulation is involved in anoxia-induced inhibition of CCDPK II activity in rat hippocampus and striatum.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8309}
}