@article{APS8267,
author = {Zafar Iqbal and John M Midgley and David G Watson and Stilianous D Karditsas and Gordon N Dutton and William S Wilson},
title = {Effect of oral administration of vitamin C on human aqueous humor ascorbate concentration.},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM:
To study oral administration of vitamin C on human aqueous humour ascorbate concentration.
METHODS:
High performance liquid chromatography (HPLC) coupled with electrochemical detector (ECD) was used. The effect of oral administration of various doses of ascorbic acid, 0 (control), 1.0, 1.5, 2.0, 3.0, and 5.0 g, on its concentration in aqueous humour, obtained from volunteer cataract patients was studied.
RESULTS:
The concentration of ascorbic acid in aqueous humour of control group (without administration of vitamin-C tablet or drug containing ascorbic acid was (254 +/- 119) mg.L-1. This study revealed that the administration of 2.0 g of ascorbic acid saturate the aqueous humour and further increase in the dose (3.0 g and 5.0 g) did not increase its concentration in aqueous humour, although its concentration was increased in plasma.
CONCLUSION:
Oral administration of 2.0 g of Vc is sufficient to saturate the aqueous humour where it may be helpful in controlling the intra-ocular pressure.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8267}
}