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Cytokines enhance nitric oxide production from human BT325 astrocytoma cells.

   
@article{APS8245,
	author = {Hong-wei Zhao and Xiao-yu Li},
	title = {Cytokines enhance nitric oxide production from human BT325 astrocytoma cells.},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {8},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the effects of lipopolysaccharides (LPS) and pre-inflammatory cytokines on nitric oxide (NO) production from cultured astrocytes.
METHODS:
Nitrites in supernatants were measured with Griess assay.
RESULTS:
The NO production from cultured human BT325 astrocytoma cells started when cultured for 4 h, reached the peak concentration (15.0 mumol.L-1) at 12 h, maintained a high level (15.0-17.5 mumol.L-1) up to 72 h, and was enhanced by LPS 1 mg.L-1, interferon-gamma (IFN-gamma) 100 kU.L-1, tumor necrosis factor-alpha (TNF-alpha) 100 kU.L-1, interleukin (IL)-1 100 kU.L-1, or IL-2 100 kU.L-1. The enhancements of TNF-alpha, IL-1, IL-2, or the mixture of the above four cytokines were higher.
CONCLUSION:
Stimulants and pre-inflammatory cytokines enhance astrocytes producing NO.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8245}
}