@article{APS8244,
author = {Yun-lin Shi and Guo-fu Li and Jing-hua Zhao and Jun-de Yang and De-ben Ding},
title = {Schizontocidal effects of oral artesunate on Plasmodium berghei in mice and P knowlesi in monkeys.},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {8},
year = {2016},
keywords = {},
abstract = {AIM:
To study the blood schizontocidal effect of oral artesunate on P berghei in mice and P knowlesi in monkey.
METHODS:
Effects of artesunate and chloroquine were detected with \"\"4-day test\"\" and \"\"28-day test\"\" on P berghei in mice and \"\"7-day test\"\" on P knowlesi in Macaca mudatta.
RESULTS:
The suppressive efficacy of oral artesunate was inferior to chloroquine on P berghei K173 strain but the time for 50% and 90% reduction and the time of clearance of parasitemia was 10-15 h shorter than that of chloroquine. Its curative effect on RC/K173 line was markedly superior to that of chloroquine. Moreover, artesunate showed no cross-resistance with chloroquine, index of resistance I90 was only 1.4. At 31.6, 10.0, and 3.16 mg.kg-1, artesunate and chloroquine oral administrations cured P knowlesi in all monkeys. Recrudescence did not occur in 105 d.
CONCLUSION:
The study of effects of oral artesunate in P berghei/mice and P knowlesi/Macaca mulatta model provided a useful index for clinical trial.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8244}
}