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General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice

  
@article{APS8214,
	author = {Qing-long GUO and Qi-dong YOU and Zhao-qiu WU and Sheng-tao YUAN and Li ZHAO},
	title = {General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {25},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the inhibitory effect of general gambogic acids (GGA) on transplantation tumor SMMC-7721 in experimental animal model and SMMC-7721 cells in vitro.
METHODS:
Anti-tumor activity of GGA in the experimental transplantation tumor SMMC-7721 was evaluated by relative tumor growth ratio. Cell morphology was observed with inverted microscope and electron microscope. Cell proliferation was measured by MTT assay and the telomerase activity was determined by PCR.
RESULTS:
In vivo study indicated that GGA (2, 4, and 8 mg/kg, iv, 3 times per week for 3 weeks) displayed an inhibitory effect on the growth of transplantation tumor SMMC-7721 in nude mice compared with the normal saline group (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8214}
}