@article{APS8209,
author = {Hong-lan WANG and De-zai DAI and Feng GAO and Yan-pin ZHANG and Feng LU},
title = {Dispersion of ventricular mRNA of RyR2 and SERCA2 associated with arrhythmogenesis in rats},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {6},
year = {2016},
keywords = {},
abstract = {AIM:
To investigate the effect of CPU86017 on the changes of mRNA abundance of different calcium handling system in infarcted heart.
METHODS:
Rats were subjected to left coronary ligation to induce myocardial infarction (MI). The treatment with either propranolol (Pro) 5 mg/kg ip or CPU86017 1, 2, and 4 mg/kg ip was initiated on the next day of operation and continued for 20 d. Medication with isoproterenol (Isop) 3 mg/kg sc started on the d 17-21. Ventricular mRNA abundance of ryanodine receptor 2 (RyR2), sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2), L-type Ca(2+) channel, and Na(+)/Ca(2+)exchanger (NCX1) were measured.
RESULTS:
Arrhythmic scores (AS) in the Isop group was raised up to 5.27+/-1.75 (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8209}
}