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Monosialoganglioside protected ischemic rat hippocampal slices through stabilizing expression of N-methyl-D-aspartate receptor subunit

   
@article{APS8207,
	author = {Jian-ren LIU and Mei-ping DING and Er-qing WEI and Jian-zheng HUANG and Ying SONG and Qiang DING and Qiu-fu GE},
	title = {Monosialoganglioside protected ischemic rat hippocampal slices through stabilizing expression of N-methyl-D-aspartate receptor subunit},
	journal = {Acta Pharmacologica Sinica},
	volume = {25},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To determine direct protective effect of monosialoganglioside (GM1) on hippocampal slices after oxygen-glucose deprivation and reperfusion (OGD/RP), and investigate the influence on the expression of N-methyl-D-aspartate receptor subunit 1 (NMDAR1) in those hippocampal slices.
METHODS:
Injury of hippocampal slices and protective effects of GM1 were detected by 2,3,5-triphenyltetrazolium chloride (TTC) staining, toluidine blue staining, and transmission electron microscopy of rat hippocampal slices. Expression of NMDAR1 was detected by Western blot.
RESULTS:
(1) GM1 at 1.0 micromol/L was the most effective concentration to preserve the TTC staining of the hippocampal slices after OGD/RP (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8207}
}