@article{APS8162,
author = {Hussien Hamed Khan and De-Zai Dai and Da-Wei Xiao and Sheng Lin and Zi-Zheng Wang and Sheng Lou and Qing Qing},
title = {Plasma CPU-86017 concentrations regarding suppression of ouabain-induced cardiac arrhythmias and decrease of heart rate in guinea pigs},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {11},
year = {2016},
keywords = {},
abstract = {\"AIM:
To determine the effective plasma levels of CPU-86017 which could suppress the cardiac arrhythmias induced by i.v. ouabain in guinea pigs.
METHODS:
The cardiac arrhythmias and the heart rate were monitored by ECG traces. Blood samples were collected to determine plasma levels using HPLC assay. TXB2 and 6-keto-PGF1 alpha were measured in plasma.
RESULTS:
The plasma concentrations of CPU-86017 which were effective to suppress ventricular fibrillation (VF) and heart rate were 0.13-0.23 mg/L and 0.13-0.31 mg/L, respectively. A reduction of TXB2 levels and an elevation of 6-keto-PGF1 alpha levels were observed after CPU-86017 i.v. administration.
CONCLUSION:
The arrhythmia-suppressing and heart rate-slowing effect of CPU-86017 followed a linear relationship with its concentrations in plasma.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8162}
}