@article{APS8152,
author = {Yong Chen and Yi-Hong Zhang and Bi-Hua Bie and Zhi-Qi Zhao},
title = {Sympathectomy induces novel purinergic sensitivity in sciatic afferents},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {11},
year = {2016},
keywords = {},
abstract = {\"AIM:
To test the hypothesis that sympathectomy could induce novel purinergic sensitivity in sciatic afferents.
METHODS:
Teased-fiber recordings were made from 32 spontaneously active A afferents from the sciatic nerves in surgically sympathectomized rats and 30 spontaneously active A afferents from the sciatic nerves in intact rats. Adenosine 5'-triphosphate (ATP) was injected via a cannula in jugular vein.
RESULTS:
Twenty eight percent of the spontaneously active afferent fibers from sciatic nerves in the sympathectomized rats responded to ATP, either with an increase or with a decrease in spontaneous firing. However, none of the fibers from the sciatic nerves in the intact rats was activated by ATP.
CONCLUSION:
Sympathectomy induces novel purinergic sensitivity in A afferents from sciatic nerve.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8152}
}