@article{APS8127,
author = {Xiao-Chao Ma and Ying Wang and Jian-Hua Liu and Zeng-Hong Tu},
title = {Moclobemide-induced gynecomastia in rats},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {10},
year = {2016},
keywords = {},
abstract = {\"AIM:
To study the toxic effect of moclobemide on male breast and to elucidate its mechanism of action.
METHODS:
Routine histopathological analysis was used to diagnose the effect of moclobemide on male breast in rats. Plasma concentrations of estrogen, androgen, and prolactin were measured by a ratioimmunometer and relative receptors of mammary gland tissue were detected immunohistochemically.
RESULTS:
After 180-d moclobemide treatment, the presence of gynecomastia was 0, 5, 5, 7/10 rats in 0, 60, 240, and 600 mg/kg groups, respectively. After 30-d convalescence, only one rat in 600 mg/kg group got the incidence of gynecomastia. Serum prolactin concentration had a trend to decrease with increasing dose and prolactin receptors in mammary gland were up-regulated.
CONCLUSION:
Long-term treatment with moclobemide causes gynecomastia in rats, which is reversible. The mechanism of moclobemide-induced gynecomastia may be related to the increase in prolactin receptors in mammary glands.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8127}
}