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Inhibitory effects of purified green tea epicatechins on contraction and proliferation of arterial smooth muscle cells

  
@article{APS8112,
	author = {Zhen-Yu Chen and Wai-Ip Law and Xiao-Qiang Yao and Chi-Wai Lau and Water Kwok Keung Ho and Yu Huang},
	title = {Inhibitory effects of purified green tea epicatechins on contraction and proliferation of arterial smooth muscle cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {21},
	number = {9},
	year = {2016},
	keywords = {},
	abstract = {\"AIM:
The present study was aimed to examine the vasorelaxant and antiproliferative responses to purified green tea epicatechin mixture, (-)epicatechin and (-)epigallocatechin gallate on rat arterial smooth muscle cells.
METHODS:
Changes in isometric force were measured by Grass force transducer and effects on cell proliferation were evaluated using [3H]thymidine incorporation assay.
RESULTS:
Epicatechin mixture, (-)epicatechin and (-)epigallocatechin gallate, which we isolated and purified from jasmine green tea, concentration-dependently, reduced the contractile response to phenylephrine in rat isolated aortic rings with (-)epigallocatechin gallate being more effective. These three agents also inhibited [3H]thymidine incorporation into DNA in cultured rat aortic smooth muscle cells in a concentration-dependent manner.
CONCLUSION:
The purified epicatechin derivatives from jasmine green tea relaxed the isolated rat arteries preconstricted by phenylephrine and inhibited aortic smooth muscle cell proliferation.\"},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8112}
}