@article{APS8110,
author = {Xiao-yan ZHAO and Qiang-min XIE and Ji-qiang CHEN and Chuan-kui KE},
title = {Inhibitory effects of cryptoporus polysaccharide on airway constriction, eosinophil release, and chemotaxis in guinea pigs},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM:
To study effects of cryptoporus polysaccharide (CP) on antigen-induced bronchoconstriction, eosinophil peroxidase (EPO) release in vivo, and on platelet activating factor (PAF)-induced eosinophil chemotaxis in vitro in guinea pig.
METHODS:
The asthma model of guinea pig was formed with ovalbumin (OVA). The changes of lung resistance (R(L)) and dynamic lung compliance (C(dyn)), EPO level in bronchoalveolar lavage fluids (BALF) and eosinophil migration were determined.
RESULTS:
Pretreatment of CP at doses of 3, 9, and 27 mg/kg by intragastric gavage (i.g.), qd for 10 d, inhibited early asthma response in a dose-dependent manner. Inhibitory rates of mean increase value from 1 to 30 min of R(L) were 34.8 %, 74.4 % (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8110}
}