@article{APS8106,
author = {Zhong Chen and Chiaki Kamei},
title = {Facilitating effects of histamine on spatial memory deficit induced by scopolamine in rats},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {9},
year = {2016},
keywords = {},
abstract = {\"AIM:
To investigate whether or not histamine was involved in scopolamine-induced spatial memory deficits evaluated in 8-arm radial maze performance of rats.
METHODS:
Eight-Arm radial maze performance was used to measure spatial memory in rats, and the brain regions were subsequently dissected and histamine contents were determined by HPLC.
RESULTS:
Intracerebroventricular (icv) injection of histamine (100 or 200 ng) or thioperamide (50 micrograms), and intraperitoneal (i.p.) injection of histidine (1000 mg/kg) ameliorated memory impairment induced by scopolamine regarding both parameters of radial maze performance. 2-Thiazolylethylamine, but not 4-methylhistamine showed the similar effect to histamine. Both histamine (200 ng, icv) and histidine (1000 mg/kg, i.p.) were equally effective in increasing the histamine content in the cortex, hippocampus, and hypothalamus.
CONCLUSION:
These results suggest that brain histamine plays an important role in learning and memory, and its action may be due to cholinergic neurons.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8106}
}