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Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism

   
@article{APS8072,
	author = {Yin-ye WANG and Zhi-yu TANG and Min DONG and Xiao-yan LIU and Shi-qi PENG},
	title = {Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism},
	journal = {Acta Pharmacologica Sinica},
	volume = {25},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To observe the oral anti-platelet efficacy and the potential action mechanism of polyaspartoyl L-arginine (PDR), a new L-arginine rich compound.
METHODS:
Platelet aggregation was conducted by Born's method; bleeding time was determined using tail's bleeding time in mice; platelet adhesion was carried out with glass bottle method; nitric oxide (NO) was tested with Griess's method; and cAMP, thromboxane B(2) (TXB(2)) and 6-keto-PGF(1 alpha ) were assessed with commercial kits.
RESULTS:
The inhibition by PDR (15-60 mg/kg i.g. or 10 mg/kg i.v.) of platelet aggregation induced by adenosine diphosphate (ADP), collagen or thrombin at 1 h after oral administration or at 20 min after i.v. injection for rats (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8072}
}