@article{APS8067,
author = {Ge-Xiu Liu and Da-Ming Ou and Jun-Hua Liu and Hong-Lin Huang and Duan-Fang Liao},
title = {Probucol inhibits lipid peroxidation of macrophage and affects its secretory properties},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {7},
year = {2016},
keywords = {},
abstract = {\"AIM:
To investigate the mechanisms of anti-atherogenic actions of probucol.
METHODS:
Human peripheral blood monocytes were cultured, and treated by copper ion (10 mumol/L) and/or probucol (PBC). Lipid peroxidation was measured by assaying malondialdehyde (MDA). The cytokine interleukin-1 beta (IL-1 beta) and apolipoprotein E (apo E) secreted by monocyte were assayed by enzyme linked immunoassay (ELISA).
RESULTS:
PBC 10-80 mumol/L inhibited copper ion-induced cellular lipid peroxidation from 15.30 to 7.74 mumol MDA/g cell protein. PBC 40 mumol/L inhibited oxidized macrophage-mediated oxidation of LDL from 5.18 to 1.65 mumol MDA/g cell protein, and attenuated secretory properties of monocytes induced by copper ion. The release of apo E, which is involved in reverse cholesterol transport, increased by 65%. And the release of IL-1 beta, which was shown to enhance vascular smooth muscle cell proliferation, decreased by 45%.
CONCLUSION:
Probucol inhibits lipid peroxidation of macrophages and affects their secretory properties.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8067}
}