@article{APS8066,
author = {Jian-Nong Wang and Ying-Jie Chen and Yoshio Hano and Taro Nomura and Ren-Xiang Tan},
title = {Antioxidant activity of polyphenols from seeds of Vitis amurensis in vitro},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {7},
year = {2016},
keywords = {},
abstract = {\"AIM:
To study the antioxidant action of five polyphenols (+) catechin, procyanidin B2, procyanidin B5, procyanidin B5 3'-O-gallate, and amurensisin isolated from the seeds of Vitis amurensis.
METHODS:
The mouse liver homogenate lipid peroxidation assay was applied for the evaluation of the antioxidant activity in vitro.
RESULTS:
(+) Catechin, procyanidin B2, procyanidin B5, procyanidin B5 3'-O-gallate, and amurensisin showed antioxidant activity with the IC50 values of 0.47, 0.25, 0.10, 0.02, and 0.03 mmol/L, respectively. The IC50 value of vitamin E used as a positive control was 0.13 mmol/L. The structural activity relationship was also analyzed. Procyanidins carrying a galloyl group possessed higher anti-lipid peroxidation activities. All dimers were found to be more potent than the non-galloylated momomer such as (+) catechin. However, the activity of the 4-->6 linked dimer seemed more preferable than 4-->8 linked dimer.
CONCLUSION:
Procyanidin B5, procyanidin B5 3'-O-gallate, and amurensisin showed a more antioxidant activity than vitamin E did, and their activity is dependent on their substitution and polymerization patterns.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8066}
}