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Disruption of estrogen receptor beta in mice brain results in pathological alterations resembling Alzheimer disease

   
@article{APS8056,
	author = {Qing-hong ZHANG and Yan-hong HUANG and Yu-zhen HU and Geng-ze WEI and Xue-feng HAN and Shun-yan LU and Yu-feng ZHAO},
	title = {Disruption of estrogen receptor beta in mice brain results in pathological alterations resembling Alzheimer disease},
	journal = {Acta Pharmacologica Sinica},
	volume = {25},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the pathological characteristics of the mice with estrogen receptor beta (ER beta) disruption in brain.
METHODS:
Immunohistochemistry method was applied in the study.
RESULTS:
beta-Amyloid peptide(A beta (42)) and apolipoprotein E (ApoE) immunoreactive substances were accumulated notably in cortex and limbic structures such as the hippocampus and amygdala in brain, resembling the pathological changes of human Alzheimer disease(AD). A beta formed cloudy-like deposits in parenchyma of brain, while apoE also deposited along or surrounding the blood vessels.
CONCLUSIONS:
ER beta is crucial to the development of neural degenerative disease, so modulation of A beta metabolism via ER beta signal pathway might be beneficial for AD prevention or therapy.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8056}
}