How to cite item

Interaction between human interleukin-16 and CD4 receptor of HIV-1

   
@article{APS8039,
	author = {Jie Yang and Ci-Quan Liu},
	title = {Interaction between human interleukin-16 and CD4 receptor of HIV-1},
	journal = {Acta Pharmacologica Sinica},
	volume = {21},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {\"AIM:
To study the interaction between human interleukin-16 (IL-16) and the receptor CD4 (T-lymphocyte differentiation antigen) of human immunodeficiency virus type 1 (HIV-1).
METHODS:
Two structurally conserved regions (SCRs) of human IL-16 were built by the SYBYL/Biopolymer module using the corresponding transmembrane (TM) domain of human interleukin-4 (HIL-4) and HIL-2 as the templates. The coordinates for amino-terminal residue sequence, carboxyl-terminal residue sequences, and cytoplasm loops were generated using Biopolymer's LOOP SEARCH algorithm.
RESULTS:
HIL-16 first formed a homodimer, then contacted with CD4 dimer further forming a dimeric complex. Subsequently, the dimeric complex constructed the tetrameric complex by two disulfide bridges between the cysteines of HIL-16 (Cys31-Cys31).
CONCLUSION:
The interaction model is useful to propose the action mechanism of HIL-16 and is beneficial for rational designing of novel anti-HIV drugs.\"},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8039}
}