@article{APS8024,
author = {Jin-Hui Yuan and Xing-Wang Wang and Dan Luo and Yong Xie and Hong Xie},
title = {Anti-hepatoma activity of taxol in vitro},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {5},
year = {2016},
keywords = {},
abstract = {\"AIM:
To investigate the in vitro anti-hepatoma activity of taxol against SMMC-7721 human hepatoma cells.
METHODS:
The hepatoma cell growth was measured by MTT-microculture tetrazolium assay. Cell-cycle kinetics and apoptosis were analyzed by flow cytometry and microscopic examination.
RESULTS:
Taxol inhibited the hepatoma cell growth in concentration- and time-dependent manners with IC50 of 18.96 nmol.L-1. Marked cell accumulation in G2/M phase and multinucleated cells were also observed after treatment with taxol 10 nmol.L-1. In addition, taxol at 10 nmol.L-1 could induce the apoptosis of hepatoma cells.
CONCLUSION:
Taxol suppresses the growth of SMMC-7721 human hepatoma cells in vitro by causing cell-cycle arrest, aberrant mitosis, and apoptosis of the human hepatoma cells.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8024}
}