@article{APS8019,
author = {Hong Ni and Zhen-Hua Lu and Shou-Biao Wang and Ming Tang},
title = {A transient increase in CCK mRNA levels in hippocampus following audiogenic convulsions in audiogenic seizure-prone rats},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {5},
year = {2016},
keywords = {},
abstract = {\"AIM:
To examine the effects of a single convulsion and multiple convulsions on cholecystokinin (CCK) mRNA expression in hippocampus of audiogenic seizure-prone rats (P77PMC).
METHODS:
Ringing (electric bell, 100 dB, 60 s) was used to induce convulsions, hippocampal CCK mRNA expression was exhibited by in situ hybridization.
RESULTS:
1) The number of CCK mRNA-positive neurons in principal hippocampus of normal rats was 34 +/- 5, which elevated markedly after a single (155 +/- 7, P < 0.01) or multiple convulsions (95 +/- 8, P < 0.01). 2) CCK mRNA levels in multiple consecutive convulsion rats were lower than that in a single convulsion rats (P < 0.01).
CONCLUSION:
The increased number of CCK mRNA-positive neurons in hippocampus may have important functional consequences in convulsion-associated processes.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8019}
}