@article{APS7941,
author = {Xia Xie and Jiang-ke Tian and Fa-qin Lv and Rong Wu and Wen-bo Tang and Yu-kun Luo and Ya-qin Huang and Jie Tang},
title = {A novel hemostatic sealant composed of gelatin, transglutaminase and thrombin effectively controls liver trauma-induced bleeding in dogs},
journal = {Acta Pharmacologica Sinica},
volume = {34},
number = {7},
year = {2016},
keywords = {},
abstract = {Xia XIE1, 2, Jiang-ke TIAN3, Fa-qin LV1, Rong WU4, Wen-bo TANG1, Yu-kun LUO1, Ya-qin HUANG5, Jie TANG1, *
1Department of Ultrasound, Chinese People’s Liberation Army General Hospital, Beijing 100853, China; 2Tsinghua University, Beijing 100084, China; 3Department of Ultrasound, Chinese People’s Liberation Army 302 Hospital, Beijing 100039, China; 4Department of Ultrasound, Erdos Central Hospital, Erdos 017000, China; 5Department of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Aim: A novel hemostatic sealant based on the in situ gel formation of gelatin catalyzed by thrombin and crosslinked by transglutaminase was designed. The aim of this study was to investigate the efficacy of the hemostatic sealant in control of bleeding caused by liver trauma in dogs.
Methods: Hepatic trauma that mimicked the grade III–IV rupture of liver was made in 20 dogs. The traumatic lesion was topically administered the hemostatic sealant (treatment group, n=10), or a thrombin solution (control group, n=10). The time to achieve hemostasis and the blood loss were measured. Contrast-enhanced ultrasound (CEUS) examination was performed in each animal on d 3, d 7, and d 10 d postoperatively to study the healing of the lesions.
Results: The mean time to achieve hemostasis in the treatment group was significantly shorter than that in the control group (1.20±0.33 vs 6.70±0.64 min, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7941}
}