@article{APS7914,
author = {Xiao-Ying Wang and Jun-Tian Zhang},
title = {NO mediates ginsenoside Rg1-induced long-term potentiation in anesthetized rats},
journal = {Acta Pharmacologica Sinica},
volume = {22},
number = {12},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the effect of ginsenoside Rg1 on synaptic transmission in anesthetized rats and the effect of NOS inhibitor, 7-nitroindazole (7-NI), on long-term potentiation (LTP) induced by Rg1.
Methods: Extracellular recording technique was used to record the population spike (PS) in the dentate gyrus (DG) of anesthetized rats. Drug or vehicle injections were delivered via a cannula in the lateral cerebral ventricle.
Results: Rg1 (10 and 100 nmol/L) enhanced the basic synaptic transmission and the magnitude of LTP induced by high frequency stimulation (HFS). Selective nNOS inhibitor 7-NI (5 nmol) icv could inhibit the induction of perforant path-dentate gyrus LTP elicited by Rg1 (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7914}
}