@article{APS7903,
author = {Xin-Chang Zhou and Peng Wei and Zhao-Yuan Hu and Fei Gao and Ru-Jin Zou and Yi-Xun Liu},
title = {Role of Fas/FasL genes in azoospermia or oligozoospermia induced by testosterone undecanoate in rhesus monkey},
journal = {Acta Pharmacologica Sinica},
volume = {22},
number = {11},
year = {2016},
keywords = {},
abstract = {Aim: To investigate role of apoptosis related genes Fas/FasL in azoospermia or oligozoospermia induced by testosterone undecanoate.
Methods: TUNEL was used to detect the apoptotic signal of testicular cells. Immunohistochemistry and Western blot were used to quantitatively or qualitatively analyze the expression of these apoptosis-related proteins.
Results: After injection of testosterone undecanoate, both the apoptotic signal in germ cells and the expression of Fas/FasL in testis increased correlatively in a time-dependent manner, reaching a maximum level on day 30.
Conclusion: Fas system may initiate and regulate the germ cell apoptosis induced by testosterone undecanoate.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7903}
}