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Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells

   
@article{APS7898,
	author = {Yun-feng WAN and Xue-qing GUO and Zheng-hua WANG and Kang YING and Ming-hui YAO},
	title = {Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {25},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To investigate the regulatory effect of paclitaxel on proliferation and apoptosis in human acute leukemia HL-60 cells.
METHODS:
HL-60 cell growth was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tertrazolium bromide (MTT) colorimetric assay. Cell cycle kinetics and apoptosis were analyzed by flow cytometry and microscopic examination. In addition, DNA microarrays containing 14,400 EST elements were used to investigate the gene expression pattern of HL-60 cells exposed to paclitaxel 1 micromol/L.
RESULTS:
Paclitaxel inhibited HL-60 cell growth significantly in a dose-dependent and time-dependent manner (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7898}
}