@article{APS7892,
author = {Lin CHANG and Jian-xin XU and Jing ZHAO and Yong-zheng PANG and Chao-shu TANG and Yong-fen QI},
title = {Taurine antagonized oxidative stress injury induced by homocysteine in rat vascular smooth muscle cells},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM:
To observe protective effects of taurine on reactive oxygen species generation induced by homocysteine in rat vascular smooth muscle cells (VSMC).
METHODS:
Rat VSMC was incubated with various concentrations of homocysteine and taurine. The lactate dehydrogenase (LDH) activity which released into culture medium was elevated as an indicator for VSMC injury. The reactive oxygen species (ROS)--hydrogen peroxide (H2O2) and superoxide anion (O2(-*)) were measured with luminol or lucigenin chemiluminescence method, and the mitochondria Mn-superoxide dismutase (Mn-SOD) and catalase (CAT) were also measured in treated VSMC.
RESULTS:
LDH leakage from cultured VSMC treated with homocysteine, was increased (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7892}
}