@article{APS7887,
author = {En-sheng JI and Hua YUE and Yu-ming WU and Rui-rong HE},
title = {Effects of phytoestrogen genistein on myocardial ischemia/reperfusion injury and apoptosis in rabbits},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM:
To study the effect of genistein (GST) on rabbit heart ischemia/reperfusion (I/R) injury.
METHODS:
Rabbit heart I/R injury was induced by occluding the left anterior descending coronary artery for 45 min and reperfusing for 180 min. GST (1.0 mg/kg) was intravenously injected 5 min before heart ischemia. Hemodynamic data, infarct size, and cardiomyocytic apoptosis were measured. The pathologic changes of I/R myocardium were observed.
RESULTS:
During the I/R, heart rate, mean arterial blood pressure, myocardial oxygen consumption, left ventricular (LV) -dp/dtmax and +dp/dtmax were decreased progressively. The infarct size was occupied 60.23 %+/-3.97 % (% of area at risk) in vehicle +I/R group while GST reduced the infarct size to 39.62 %+/-4.30 % (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7887}
}