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Gonadectomy affects brain derived neurotrophic factor in rats after chronic constriction nerve injury

  
@article{APS7883,
	author = {Xin ZHAO and Xin WANG and Shu-yun ZHENG and Jian-guo XU},
	title = {Gonadectomy affects brain derived neurotrophic factor in rats after chronic constriction nerve injury},
	journal = {Acta Pharmacologica Sinica},
	volume = {25},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To assess the effect of gonadectomy on brain derived neurotrophic factor (BDNF) expression in neuropathic pain.
METHODS:
Using chronic constriction injury (CCI) model, we detected BDNF mRNA in dorsal root ganglion and protein content in spinal cord by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay respectively. The time point we chose was post CCI operation d 0, 3, 7, 14, and 21.
RESULTS:
After CCI surgery, BDNF mRNA in ipsilateral DRGs was upregulated and reached its maximum on post operation d 7. BDNF protein level in ipsilateral spinal cord was also increased and reached its maximum on post operation d 14. The magnitude of this increase in gonadectomy (GDX) rats was significantly smaller than the GDX-sham rats at each time point.
CONCLUSION:
Gonadectomy reduced the BDNF increment after CCI surgery. Estrogen may affect nociceptive processing by its effect on BDNF.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7883}
}