@article{APS7880,
author = {Yi-peng WANG and Xian-tao LI and Shi-jie LIU and Xin-wen ZHOU and Xiao-chuan WANG and Jian-zhi WANG},
title = {Melatonin ameliorated okadaic-acid induced Alzheimer-like lesions.},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM:
To explore the protective effects of melatonin (Mel) on the abnormal phosphorylation of neuronal cytoskeletal proteins.
METHODS:
We generated a neuroblastoma (SH-SY5Y) cell system in which cytoskeletal proteins are abnormally phosphorylated resulting in microtubule disruption due to the marked inhibition of protein phosphatase activities by okadaic acid (OA).
RESULTS:
OA-induced declines in cell viability and mitochondrial metabolic activity were remarkably prevented by Mel. In addition, the hyperphosphorylation/accumulation of neurofilament-(NF-) H/M subunits and the disruption of microtubules, induced by OA, were significantly inhibited by Mel.
CONCLUSION:
Our results suggest multiple protective functions of Mel against a series of pathological lesions known to culminate in AD, including abnormal phosphorylation of cytoskeletal proteins, microtubule disassembly and mitochondrion-initiated cell toxicity.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7880}
}