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A pharmacodynamic analysis of factors affecting recovery from anesthesia with propofol-remifentanil target controlled infusion

   
@article{APS7874,
	author = {Bon-nyeo Koo and Jeong-rim Lee and Gyu-jeong Noh and Jae-hoon Lee and Young-ran Kang and Dong-woo Han},
	title = {A pharmacodynamic analysis of factors affecting recovery from anesthesia with propofol-remifentanil target controlled infusion},
	journal = {Acta Pharmacologica Sinica},
	volume = {33},
	number = {8},
	year = {2016},
	keywords = {},
	abstract = {Aim: To examine individual patient’s demographic parameters and clinical variables related to return of consciousness (ROC) and the pharmacodynamic relationship between propofol effect-site concentration (Ce) and ROC from propofol-remifentanil anesthesia.
Methods: Ninety-four patients received propofol-remifentanil anesthesia using the effect-site target-controlled infusion (TCI) system. All clinical events were noted, and variables possibly related to propofol Ce at ROC were examined using linear correlation analyses. Pharmacodynamic modeling incorporating covariates was performed using NONMEM (Nonlinear Mixed Effects Modeling) VII software.
Results: The Ce values of propofol at loss of consciousness (LOC) and ROC were 4.4±1.1 μg/mL and 1.1±0.3 μg/mL, respectively. Age was negatively correlated with propofol Ce at ROC (r=−0.48, P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7874}
}